Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
taar1_human 339 C-term S => Ter stop gained 1.744e-05 1 57342 0 None None
taar1_human 324 C-term F => SerfsTer14 frameshift 9.236e-06 1 108270 0 None None
taar1_human 320 8.59x59 H8 F => LeufsTer18 frameshift 3.523e-05 4 113552 0 None None
taar1_human 291 7.40x39 TM7 W => Ter stop gained 0.0001408 17 120742 0 None None LB (hydrophobic, Van der Waals, polar (hydrogen bond))
taar1_human 258 6.42x42 TM6 G => Ter stop gained 8.265e-06 1 120998 0 None None
taar1_human 246 6.30x30 TM6 E => GlyfsTer4 frameshift 1.653e-05 2 120978 0 None None SodiumPocket MicroSwitch
taar1_human 229 5.77x77 TM5 Q => Ter stop gained 8.277e-06 1 120818 0 None None
taar1_human 227 5.75x75 TM5 A => ProfsTer11 frameshift 1.656e-05 2 120784 0 None None GP (contact)
taar1_human 210 5.58x58 TM5 Y => IlefsTer14 frameshift 8.292e-06 1 120600 0 None None SodiumPocket MicroSwitch
taar1_human 187 5.35x36 TM5 S => Ter frameshift 8.29e-06 1 120628 0 None None
taar1_human 61 2.42x42 TM2 L => SerfsTer22 frameshift 0.0001815 22 121192 0 None None
taar1_human 53 12.49x49 ICL1 Q => AsnfsTer30 frameshift 1.65e-05 2 121244 0 None None
taar1_human 18 N-term W => Ter stop gained 1.664e-05 2 120212 0 None None
taar1_human 330 C-term R => T missense 1.045e-05 1 95664 0 0.89 0.009
taar1_human 327 C-term D => V missense 9.635e-06 1 103790 0 0.02 0.323
taar1_human 325 C-term Q => E missense 9.29e-06 1 107644 0 0.28 0.15
taar1_human 318 8.57x57 H8 M => T missense 8.558e-06 1 116854 0 0.02 0.0
taar1_human 315 8.54x54 H8 L => P missense 8.455e-06 1 118270 0 0.0 0.88
taar1_human 302 7.51x51 TM7 M => T missense 3.321e-05 4 120430 0 0.0 0.158
taar1_human 300 7.49x49 TM7 N => K missense 0.0008795 106 120518 1 0.0 0.996 SodiumPocket MicroSwitch
taar1_human 300 7.49x49 TM7 N => S missense 8.296e-06 1 120538 0 0.0 0.996 SodiumPocket MicroSwitch
taar1_human 299 7.48x48 TM7 F => S missense 8.294e-06 1 120570 0 0.04 0.356
taar1_human 298 7.47x47 TM7 T => A missense 1.658e-05 2 120608 0 0.3 0.012
taar1_human 293 7.42x41 TM7 G => R missense 8.283e-06 1 120722 0 0.01 0.988 LB (Van der Waals, polar (hydrogen bond), polar (hydrogen bond with backbone))
taar1_human 287 7.36x35 TM7 D => V missense 8.273e-06 1 120876 0 0.01 0.491 LB (hydrophobic, Van der Waals, polar (hydrogen bond with backbone))
taar1_human 283 7.32x31 TM7 P => S missense 8.275e-06 1 120848 0 0.34 0.014
taar1_human 280 ECL3 I => V missense 8.274e-06 1 120864 0 0.12 0.0
taar1_human 276 6.60x60 TM6 F => I missense 1.655e-05 2 120874 0 0.08 0.759
taar1_human 275 6.59x59 TM6 P => L missense 2.482e-05 3 120860 0 0.03 0.992
taar1_human 275 6.59x59 TM6 P => T missense 1.655e-05 2 120862 0 0.0 0.994
taar1_human 273 6.57x57 TM6 M => V missense 8.273e-06 1 120882 0 0.48 0.003
taar1_human 272 6.56x56 TM6 V => I missense 8.274e-06 1 120856 0 1.0 0.006
taar1_human 269 6.53x53 TM6 I => N missense 8.273e-05 10 120870 0 0.0 0.516
taar1_human 266 6.50x50 TM6 P => S missense 8.267e-06 1 120968 0 0.0 1.0 SodiumPocket MicroSwitch
taar1_human 266 6.50x50 TM6 P => A missense 8.267e-06 1 120968 0 0.0 1.0 SodiumPocket MicroSwitch
taar1_human 264 6.48x48 TM6 W => L missense 8.265e-06 1 120994 0 0.0 0.951 SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals, polar (hydrogen bond), aromatic (face-to-edge), aromatic (edge-to-face))
taar1_human 263 6.47x47 TM6 C => G missense 8.265e-06 1 120996 0 0.0 0.989
taar1_human 255 6.39x39 TM6 I => T missense 8.264e-06 1 121006 0 0.03 0.169
taar1_human 253 6.37x37 TM6 L => W missense 8.264e-06 1 121004 0 0.0 1.0 GP (contact)
taar1_human 253 6.37x37 TM6 L => V missense 8.264e-06 1 121014 0 0.0 0.986 GP (contact)
taar1_human 252 6.36x36 TM6 T => I missense 8.264e-06 1 121000 0 0.0 0.996 GP (contact)
taar1_human 252 6.36x36 TM6 T => A missense 0.001116 135 121008 0 0.02 0.999 GP (contact)
taar1_human 249 6.33x33 TM6 A => T missense 1.653e-05 2 120978 0 0.0 0.999 GP (contact)
taar1_human 247 6.31x31 TM6 R => T missense 1.653e-05 2 120976 0 0.15 0.034
taar1_human 247 6.31x31 TM6 R => K missense 8.266e-06 1 120976 0 0.26 0.02
taar1_human 245 6.29x29 TM6 K => E missense 8.266e-06 1 120978 0 0.11 0.219 GP (contact)
taar1_human 244 6.28x28 TM6 S => N missense 0.0006118 74 120954 1 0.51 0.004 GP (contact)
taar1_human 238 ICL3 K => R missense 4.135e-05 5 120930 0 0.27 0.008
taar1_human 237 ICL3 M => I missense 1.654e-05 2 120912 0 0.2 0.011
taar1_human 234 ICL3 G => R missense 8.274e-06 1 120856 0 0.33 0.013
taar1_human 229 5.77x77 TM5 Q => R missense 8.275e-06 1 120842 0 0.61 0.004
taar1_human 227 5.75x75 TM5 A => G missense 8.279e-06 1 120784 0 0.5 0.008 GP (contact)
taar1_human 227 5.75x75 TM5 A => S missense 8.28e-06 1 120778 0 0.63 0.052 GP (contact)
taar1_human 222 5.70x70 TM5 R => S missense 8.282e-06 1 120746 0 0.0 0.217
taar1_human 222 5.70x70 TM5 R => I missense 8.282e-06 1 120742 0 0.0 0.141
taar1_human 220 5.68x68 TM5 Q => P missense 8.283e-06 1 120732 0 0.02 0.992 GP (contact)
taar1_human 218 5.66x66 TM5 K => I missense 8.283e-06 1 120724 0 0.0 0.595 GP (contact)
taar1_human 218 5.66x66 TM5 K => E missense 8.285e-06 1 120706 0 0.02 0.03 GP (contact)
taar1_human 217 5.65x65 TM5 A => T missense 0.000174 21 120678 0 0.0 1.0 GP (contact)
taar1_human 217 5.65x65 TM5 A => S missense 1.657e-05 2 120678 0 0.24 1.0 GP (contact)
taar1_human 212 5.60x60 TM5 R => T missense 8.291e-06 1 120606 0 0.0 0.857
taar1_human 198 5.46x461 TM5 S => Y missense 1.659e-05 2 120532 0 0.03 0.883 LB (polar (hydrogen bond), Van der Waals)
taar1_human 197 5.45x46 TM5 T => I missense 2.489e-05 3 120520 0 1.0 0.002 LB (polar (hydrogen bond), Van der Waals)
taar1_human 195 5.43x44 TM5 F => L missense 4.147e-05 5 120578 0 0.13 0.038
taar1_human 190 5.38x39 TM5 S => C missense 8.292e-06 1 120604 0 0.12 0.778
taar1_human 182 45.50x50 ECL2 C => F missense 4.143e-05 5 120680 0 0.0 0.986 LB (polar (hydrogen bond with backbone), Van der Waals)
taar1_human 181 ECL2 G => V missense 0.0001657 20 120670 0 0.39 0.027
taar1_human 174 ECL2 K => Q missense 8.288e-06 1 120654 0 0.56 0.014
taar1_human 174 ECL2 K => E missense 1.658e-05 2 120654 0 1.0 0.008
taar1_human 173 ECL2 Y => H missense 0.0002569 31 120652 0 0.44 0.013
taar1_human 172 ECL2 Y => C missense 0.000547 66 120650 3 0.0 0.967
taar1_human 172 ECL2 Y => D missense 8.289e-06 1 120640 0 0.0 0.956
taar1_human 171 ECL2 I => L missense 0.0001907 23 120638 0 0.61 0.002
taar1_human 170 ECL2 E => K missense 8.29e-06 1 120622 0 0.07 0.052
taar1_human 169 ECL2 E => A missense 8.291e-06 1 120610 0 0.02 0.904
taar1_human 168 ECL2 A => S missense 8.29e-06 1 120620 0 0.19 0.049
taar1_human 167 ECL2 G => D missense 4.974e-05 6 120636 0 0.01 0.982
taar1_human 167 ECL2 G => S missense 8.289e-06 1 120638 0 0.02 0.992
taar1_human 162 4.64x64 TM4 E => D missense 1.658e-05 2 120640 0 0.11 0.02
taar1_human 162 4.64x64 TM4 E => Q missense 8.29e-06 1 120622 0 0.06 0.1
taar1_human 159 4.61x61 TM4 I => T missense 3.314e-05 4 120702 0 0.0 0.491
taar1_human 159 4.61x61 TM4 I => N missense 1.657e-05 2 120702 0 0.0 0.981
taar1_human 158 4.60x60 TM4 M => I missense 8.286e-06 1 120688 0 0.14 0.042
taar1_human 154 4.56x56 TM4 F => L missense 9.935e-05 12 120784 0 0.09 0.013 LB (hydrophobic, Van der Waals)
taar1_human 152 4.54x54 TM4 A => D missense 8.279e-06 1 120792 0 0.03 0.824
taar1_human 151 4.53x53 TM4 P => A missense 8.277e-06 1 120812 0 0.11 0.789 LB (hydrophobic, Van der Waals)
taar1_human 135 34.57x57 ICL2 M => I missense 8.274e-06 1 120854 0 1.0 0.006 GP (contact)
taar1_human 134 34.56x56 ICL2 K => E missense 8.273e-06 1 120874 0 0.0 0.794 PTM (Methylation) GP (contact)
taar1_human 129 34.51x51 ICL2 L => P missense 4.136e-05 5 120894 0 0.0 1.0 GP (contact)
taar1_human 123 3.52x52 TM3 Y => C missense 0.0001075 13 120924 0 0.05 0.182
taar1_human 123 3.52x52 TM3 Y => H missense 1.654e-05 2 120918 0 0.01 0.417
taar1_human 121 3.50x50 TM3 R => L missense 8.27e-06 1 120912 0 0.0 0.997 SodiumPocket MicroSwitch GP (contact)
taar1_human 121 3.50x50 TM3 R => C missense 0.0001406 17 120926 0 0.03 0.999 SodiumPocket MicroSwitch GP (contact)
taar1_human 119 3.48x48 TM3 I => F missense 4.134e-05 5 120938 0 0.0 0.103
taar1_human 117 3.46x46 TM3 I => V missense 8.268e-06 1 120944 0 0.14 0.923
taar1_human 115 3.44x44 TM3 S => C missense 4.134e-05 5 120940 0 1.0 0.028
taar1_human 115 3.44x44 TM3 S => F missense 8.269e-06 1 120940 0 0.07 0.964
taar1_human 113 3.42x42 TM3 H => R missense 0.0001075 13 120954 0 0.0 0.992
taar1_human 109 3.38x38 TM3 A => V missense 8.265e-06 1 120988 0 0.3 0.35
taar1_human 104 3.33x33 TM3 I => V missense 0.0002231 27 120998 0 0.28 0.177 LB (hydrophobic, Van der Waals)
taar1_human 103 3.32x32 TM3 D => N missense 8.264e-06 1 121006 0 0.01 0.999 LB (polar (charge-assisted hydrogen bond), Van der Waals, polar (charge-charge), hydrophobic)
taar1_human 100 3.29x29 TM3 T => I missense 1.653e-05 2 121016 0 0.04 0.213 LB (Van der Waals)
taar1_human 100 3.29x29 TM3 T => A missense 8.264e-06 1 121014 0 0.18 0.142 LB (Van der Waals)
taar1_human 99 3.28x28 TM3 H => R missense 1.653e-05 2 121028 0 0.0 0.456
taar1_human 98 3.27x27 TM3 I => T missense 8.262e-06 1 121036 0 0.0 0.809
taar1_human 94 3.23x23 TM3 V => A missense 4.13e-05 5 121060 0 0.08 0.102
taar1_human 94 3.23x23 TM3 V => L missense 8.26e-06 1 121066 0 1.0 0.001
taar1_human 80 2.61x60 TM2 S => G missense 8.255e-06 1 121136 0 0.02 0.791
taar1_human 78 2.59x58 TM2 P => S missense 8.255e-06 1 121136 0 0.0 0.997
taar1_human 77 2.58x57 TM2 M => L missense 8.254e-06 1 121156 0 0.03 0.679
taar1_human 74 2.55x55 TM2 C => Y missense 8.254e-06 1 121150 0 0.54 0.021
taar1_human 72 2.53x53 TM2 L => P missense 8.253e-06 1 121166 0 0.0 0.994 LB (polar (hydrogen bond))
taar1_human 69 2.50x50 TM2 D => G missense 8.252e-06 1 121176 0 0.01 1.0
taar1_human 65 2.46x46 TM2 M => I missense 8.252e-06 1 121188 0 0.01 0.403
taar1_human 64 2.45x45 TM2 S => F missense 3.301e-05 4 121188 0 0.0 1.0
taar1_human 63 2.44x44 TM2 H => N missense 2.475e-05 3 121198 0 0.03 0.008
taar1_human 59 2.40x40 TM2 N => D missense 1.65e-05 2 121202 0 0.0 0.999
taar1_human 58 2.39x39 TM2 T => K missense 8.25e-06 1 121210 0 0.03 0.98
taar1_human 55 12.51x51 ICL1 H => R missense 8.249e-05 10 121230 0 0.01 0.679
taar1_human 51 1.60x60 TM1 F => L missense 6.598e-05 8 121242 0 0.0 0.999
taar1_human 50 1.59x59 TM1 H => Q missense 8.248e-06 1 121246 0 0.01 0.61
taar1_human 49 1.58x58 TM1 S => L missense 0.0003794 46 121246 0 0.13 0.004
taar1_human 48 1.57x57 TM1 I => T missense 8.249e-06 1 121234 0 0.0 0.903
taar1_human 47 1.56x56 TM1 S => C missense 9.897e-05 12 121246 0 0.0 0.829
taar1_human 45 1.54x54 TM1 I => M missense 8.247e-06 1 121262 0 0.07 0.644
taar1_human 42 1.51x51 TM1 L => M missense 2.474e-05 3 121282 0 0.16 0.724
taar1_human 41 1.50x50 TM1 N => D missense 8.245e-06 1 121288 0 0.0 1.0
taar1_human 40 1.49x49 TM1 G => S missense 8.245e-06 1 121292 0 0.01 1.0
taar1_human 39 1.48x48 TM1 V => I missense 1.649e-05 2 121292 0 0.5 0.003
taar1_human 38 1.47x47 TM1 L => I missense 8.244e-06 1 121296 0 0.49 0.002
taar1_human 38 1.47x47 TM1 L => F missense 2.473e-05 3 121296 0 0.03 0.014
taar1_human 36 1.45x45 TM1 T => N missense 8.244e-06 1 121296 0 0.0 0.243
taar1_human 36 1.45x45 TM1 T => A missense 1.649e-05 2 121298 0 0.26 0.002
taar1_human 28 1.37x37 TM1 S => C missense 0.0006102 74 121264 2 0.18 0.008
taar1_human 26 1.35x35 TM1 L => R missense 4.126e-05 5 121196 0 0.0 0.903
taar1_human 24 1.33x33 TM1 A => T missense 8.262e-06 1 121034 0 0.35 0.045
taar1_human 23 1.32x32 TM1 R => H missense 0.000157 19 121016 0 0.06 0.028
taar1_human 23 1.32x32 TM1 R => L missense 8.263e-06 1 121016 0 0.09 0.491
taar1_human 23 1.32x32 TM1 R => C missense 0.001546 187 120980 1 0.03 0.048
taar1_human 20 N-term N => S missense 8.297e-06 1 120526 0 0.76 0.002
taar1_human 18 N-term W => C missense 8.319e-06 1 120212 0 0.15 0.447
taar1_human 18 N-term W => G missense 0.001324 159 120096 1 0.26 0.053
taar1_human 18 N-term W => R missense 1.665e-05 2 120096 0 0.94 0.001
taar1_human 16 N-term N => S missense 8.365e-06 1 119550 0 1.0 0.0
taar1_human 16 N-term N => Y missense 8.374e-06 1 119424 0 0.37 0.001
taar1_human 13 N-term C => Y missense 8.437e-06 1 118524 0 0.01 0.094
taar1_human 9 N-term I => N missense 2.561e-05 3 117158 0 0.15 0.007
taar1_human 3 N-term P => S missense 8.703e-06 1 114908 0 0.47 0.001


Residue

Diagrams

ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
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